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Umbilical cord blood levels of maternal antibodies reactive with p200 and full-length Ro 52 in the assessment of risk for cardiac manifestations of neonatal Lupus

Reed, Joanne H; Clancy, Robert M; Lee, Kristen H; Saxena, Amit; Izmirly, Peter M; Buyon, Jill P


Objective Maternal anti-Ro autoantibodies are associated with cardiac manifestations of neonatal lupus (cardiac NL), yet only 2% of women with this reactivity have an affected child. Identification of a more specific marker would channel intense monitoring to fetuses at greater risk. This study aimed to determine whether autoantibodies against Ro 52 amino acids 200–239 (p200) confer added risk over autoantibodies to full-length Ro 52, Ro 60, or La. Methods Anti-Ro–exposed pregnancies...[Show more]

CollectionsANU Research Publications
Date published: 2012-09
Type: Journal article
Source: Arthritis Care and Research 64.9(2012): 1373–1381
DOI: 10.1002/acr.21704


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