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Ro60 requires Y3 RNA for cell surface exposure and inflammation associated with cardiac manifestations of neonatal lupus

Reed, Joanne H; Sim, Soyeong; Wolin, Sandra L; Clancy, Robert M; Buyon, Jill P


Cardiac neonatal lupus (NL) is presumed to arise from maternal autoantibody targeting an intracellular ribonucleoprotein, Ro60, which binds noncoding Y RNA and only becomes accessible to autoantibodies during apoptosis. Despite the importance of Ro60 trafficking in the development of cardiac NL, the mechanism underlying cell surface exposure is unknown. To evaluate the influence of Y RNA on the subcellular location of Ro60 during apoptosis and activation of macrophages, stable Ro60 knockout...[Show more]

CollectionsANU Research Publications
Date published: 2013-07-01
Type: Journal article
Source: The Journal of Immunology 191.1 (2013): 110-116
DOI: 10.4049/jimmunol.1202849


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