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A central role of plasmin in cardiac injury initiated by fetal exposure to maternal anti-Ro autoantibodies

Briassouli, Paraskevi; Halushka, Marc K; Reed, Joanne H; Molad, Yair; Fox-Talbot, Karen; Buyon, Lucas; Guzman, Edwin; Ludomirsky, Achiau; Clancy, Robert M; Buyon, Jill P


Objective. Cardiac neonatal lupus (cardiac-NL), initiated by surface binding of anti-Ro60 autoantibodies to apoptotic cardiocytes during development, activates the urokinase plasminogen activator/urokinase plasminogen activator receptor (uPA/uPAR) system. Subsequent accumulation of apoptotic cells and plasmin generation facilitates increased binding of anti-Ro60 by disrupting and cleaving circulating β2-glycoprotein I (β2GPI) thereby eliminating its protective effect. The association of soluble...[Show more]

CollectionsANU Research Publications
Date published: 2013-04-18
Type: Journal article
Source: Rheumatology 52.8 (2013):1448-1453
DOI: 10.1093/rheumatology/ket156


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