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Partial dysfunction of STAT1 profoundly reduces host resistance to flaviviral infection

Larena, Maximilian; Lobigs, Mario

Description

The genetic basis for a dramatically increased virus susceptibility phenotype of MHC-II knockout mice acquired during routine maintenance of the mouse strain was determined. Segregation of the susceptibility allele from the defective MHC-II locus combined with sequence capture and sequencing showed that a Y37L substitution in STAT1 accounted for high flavivirus susceptibility of a newly derived mouse strain, designated Tuara. Interestingly, the mutation in STAT1 gene gave only partial...[Show more]

CollectionsANU Research Publications
Date published: 2017-06
Type: Journal article
URI: http://hdl.handle.net/1885/114499
Source: Virology
DOI: 10.1016/j.virol.2017.03.001

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