Probing the mechanisms for the selectivity and promiscuity of methyl parathion hydrolase
Diverse organophosphate hydrolases have convergently evolved the ability to hydrolyse man-made organophosphates. Thus, these enzymes are attractive model systems for studying the factors shaping enzyme functional evolution. Methyl parathion hydrolase (MPH) is an enzyme from the metallo-β-lactamase superfamily, which hydrolyses a wide range of organophosphate, aryl ester and lactone substrates. In addition, MPH demonstrates metal-ion-dependent selectivity patterns. The origins of this remain...[Show more]
|Collections||ANU Research Publications|
|Source:||Philosophical transactions. Series A, Mathematical, physical, and engineering sciences|
|01_Purg_Probing_the_Mechanisms_2016.pdf||883.46 kB||Adobe PDF|
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