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A new link between transcriptional initiation and pre-mRNA splicing: The RNA binding histone variant H2A.B

Soboleva, Tatiana; Parker, Brian J; Nekrasov, Maxim; Hart-Smith, Gene; Tay, Ying Jin; Tng, Wei-Quan; Wilkins, Marc; Ryan, Daniel; Tremethick, David J


The replacement of histone H2A with its variant forms is critical for regulating all aspects of genome organisation and function. The histone variant H2A.B appeared late in evolution and is most highly expressed in the testis followed by the brain in mammals. This raises the question of what new function(s) H2A.B might impart to chromatin in these important tissues. We have immunoprecipitated the mouse orthologue of H2A.B, H2A.B.3 (H2A.Lap1), from testis chromatin and found this variant to be...[Show more]

CollectionsANU Research Publications
Date published: 2017-02-24
Type: Journal article
Source: PLoS genetics
DOI: 10.1371/journal.pgen.1006633
Access Rights: Open Access


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