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Investigation into the prevalence of a novel dendritic-like cell subset in vivo

Griffiths, Kristin Lisa; Tan, Jonathan Kah Huat; O’Neill, Helen Christine

Description

A novel dendritic-like cell subset termed L-DC was recently identified in murine spleen based on marker expression of a homogeneous cell population derived from long-term culture of neonatal spleen. The function of L-DC is distinct from other splenic dendritic and myeloid cell subsets because of their high endocytic capacity and their ability to cross-present antigen to CD8+ T cells. This paper shows the subset to be unique to spleen and blood, with a similar, but possibly functionally distinct...[Show more]

CollectionsANU Research Publications
Date published: 2013-12
Type: Journal article
URI: http://hdl.handle.net/1885/11414
Source: Journal of Cellular and Molecular Medicine 17.12 (2013): 1608-1618
DOI: 10.1111/jcmm.12174

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