Updated assessment of the prevalence, spectrum and case definition of autoimmune disease
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Hayter, Scott M; Cook, Matthew C
Description
Autoimmune diseases are heterogeneous with regard to prevalence, manifestations, and pathogenesis. The classification of autoimmune diseases has varied over time. Here, we have compiled a comprehensive up-to-date list of the autoimmune diseases, and have reviewed published literature to estimate their prevalence. We identified 81 autoimmune diseases. The overall estimated prevalence is 4.5%, with 2.7% for males and 6.4% for females. For specific diseases, prevalence ranges from 1% to < 1/106....[Show more]
dc.contributor.author | Hayter, Scott M | |
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dc.contributor.author | Cook, Matthew C | |
dc.date.accessioned | 2014-02-23T23:48:28Z | |
dc.date.available | 2014-02-23T23:48:28Z | |
dc.identifier.issn | 1568-9972 | |
dc.identifier.uri | http://hdl.handle.net/1885/11411 | |
dc.description.abstract | Autoimmune diseases are heterogeneous with regard to prevalence, manifestations, and pathogenesis. The classification of autoimmune diseases has varied over time. Here, we have compiled a comprehensive up-to-date list of the autoimmune diseases, and have reviewed published literature to estimate their prevalence. We identified 81 autoimmune diseases. The overall estimated prevalence is 4.5%, with 2.7% for males and 6.4% for females. For specific diseases, prevalence ranges from 1% to < 1/106. Considering all diseases in the class, the most common mean age-of-onset was 40–50 years. This list of autoimmune diseases has also yielded information about autoantigens. Forty-five autoimmune diseases have been associated with well-defined autoantigens. Of the diseases with known autoantigens, 33.3% had highly repetitive sequences, 35.6% had coiled-coil arrangements and 57.8% were associated with cellular membranes, which means that based on these structural motifs alone, autoantigens do not appear to be a random sample of the human proteome. Finally, we identified 19 autoimmune diseases that phenocopy diseases arising from germline mutations in the corresponding autoantigen. Collectively, our findings lead to a tentative proposal for criteria for assigning autoimmune pathogenesis to a particular disease. | |
dc.format | 12 pages | |
dc.publisher | Elsevier | |
dc.rights | http://www.sherpa.ac.uk/romeo/issn/1568-9972/author can archive pre-print (ie pre-refereeing);author cannot archive publisher's version/PDF | |
dc.source | Autoimmunity Reviews 11.10 (2012): 754–765 | |
dc.subject | autoantigen | |
dc.subject | epidemiology | |
dc.subject | phenocopy | |
dc.subject | prevalence | |
dc.subject | criteria | |
dc.title | Updated assessment of the prevalence, spectrum and case definition of autoimmune disease | |
dc.type | Journal article | |
local.identifier.citationvolume | 11 | |
dcterms.dateAccepted | 2012-01-31 | |
dc.date.issued | 2012-02-23 | |
local.identifier.absfor | 110700 - IMMUNOLOGY | |
local.identifier.ariespublication | u4971216xPUB156 | |
local.publisher.url | http://www.elsevier.com/ | |
local.type.status | Published Version | |
local.contributor.affiliation | Hayter, Scott M, Australian National University Medical School | |
local.contributor.affiliation | Cook, Matthew C, Australian National University Medical School | |
local.bibliographicCitation.issue | 10 | |
local.bibliographicCitation.startpage | 754 | |
local.bibliographicCitation.lastpage | 765 | |
local.identifier.doi | 10.1016/j.autrev.2012.02.001 | |
dc.date.updated | 2015-12-08T10:58:50Z | |
local.identifier.scopusID | 2-s2.0-84864385195 | |
local.identifier.thomsonID | 000307798800010 | |
Collections | ANU Research Publications |
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