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Advances in biological dosimetry

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Ivashkevich, A; Ohnesorg, T; Sparbier, C E; Elsaleh, H

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Rapid retrospective biodosimetry methods are essential for the fast triage of persons occupationally or accidentally exposed to ionizing radiation. Identification and detection of a radiation specific molecular ‘footprint’ should provide a sensitive and reliable measurement of radiation exposure. Here we discuss conventional (cytogenetic) methods of detection and assessment of radiation exposure in comparison to emerging approaches such as gene expression signatures and DNA damage markers....[Show more]

dc.contributor.authorIvashkevich, A
dc.contributor.authorOhnesorg, T
dc.contributor.authorSparbier, C E
dc.contributor.authorElsaleh, H
dc.date.accessioned2017-03-28T22:49:36Z
dc.date.available2017-03-28T22:49:36Z
dc.identifier.issn1742-6588
dc.identifier.urihttp://hdl.handle.net/1885/114095
dc.description.abstractRapid retrospective biodosimetry methods are essential for the fast triage of persons occupationally or accidentally exposed to ionizing radiation. Identification and detection of a radiation specific molecular ‘footprint’ should provide a sensitive and reliable measurement of radiation exposure. Here we discuss conventional (cytogenetic) methods of detection and assessment of radiation exposure in comparison to emerging approaches such as gene expression signatures and DNA damage markers. Furthermore, we provide an overview of technical and logistic details such as type of sample required, time for sample preparation and analysis, ease of use and potential for a high throughput analysis.
dc.format5 pages
dc.format.mimetypeapplication/pdf
dc.publisherIOP Publishing
dc.rightsContent from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
dc.sourceJournal of Physics: Conference Series
dc.subjectbiodosimetry
dc.subjectretrospective
dc.subjectfast
dc.subjecttriage
dc.subjectoccupationally
dc.subjectaccidentally
dc.subjectionizing
dc.subjectradiation
dc.titleAdvances in biological dosimetry
dc.typeJournal article
local.identifier.citationvolume777
dc.date.issued2017
local.publisher.urlhttp://conferenceseries.iop.org
local.type.statusPublished Version
local.contributor.affiliationIvashkevich, Alesia, Genome Sciences, CMBE John Curtin School of Medical Research, The Australian National University
local.identifier.essn1742-6596
local.bibliographicCitation.issue1
local.bibliographicCitation.startpage012012
local.identifier.doi10.1088/1742-6596/777/1/012012
dcterms.accessRightsOpen Access
CollectionsANU Research Publications

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