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Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD81 T-cell memory formation and function

Ives, Megan L; Ma, Cindy; Palendira, Umaimainthan; Chan, Anna; Bustamante, Jacinta; Boisson-Dupuis, Stephanie; Arkwright, Peter D; Engelhard, Dan; Averbuch, Diana; Magdorf, Klaus; Roesler, Joachim; Peake, Jane; Wong, Melanie; Adelstein, Stephen; Choo, Sharon; Smart, Joanne M.; French, Martyn A; Fulcher, David A; Cook, Matthew C; Picard, Capucine; Durandy, Anne; Tsumura, Miyuki; Kobayashi, Masao; Uzel, Gulbu; Casanova, Jean-Laurent; Tangye, Stuart G; Deenick, Elissa K


Background The capacity of CD8+ T cells to control infections and mediate antitumor immunity requires the development and survival of effector and memory cells. IL-21 has emerged as a potent inducer of CD8+ T-cell effector function and memory development in mouse models of infectious disease. However, the role of IL-21 and associated signaling pathways in protective CD8+ T-cell immunity in human subjects is unknown. Objective We sought to determine which signaling pathways mediate the...[Show more]

CollectionsANU Research Publications
Date published: 2013-08
Type: Journal article
Source: Journal of Allergy and Clinical Immunology 132.2 (2013): 400–411.e9
DOI: 10.1016/j.jaci.2013.05.029


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