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The unfolded protein response is activated in Helicobacter-induced gastric carcinogenesis in a non-cell autonomous manner

Baird, Mhairi; Ang, Pei Woon; Clark, Ian; Bishop, Danial; Oshima, Masanobu; Cook, Matthew C; Hemmings, Christine; Takeishi, Shigeo; Worthley, Dan; Boussioutas, Alex; Wang, Timothy C; Taupin, Doug


Mucous metaplasia (MM) is an aberrant secretory phenotype that arises during Helicobacter-induced gastric carcinogenesis. HSPA5, a key modulator of the unfolded protein response (UPR) activated by endoplasmic reticulum (ER) stress is overexpressed in gastric cancer (GC). We studied activation of the UPR in MM and GC in humans and mice. We assessed RNA and protein levels of ER stress markers (HSPA5, XBP1, and CHOP) in human GC, and correlated with Helicobacter pylori (H. pylori) status, then...[Show more]

CollectionsANU Research Publications
Date published: 2013-01
Type: Journal article
Source: Laboratory Investigation 93.1 (2013): 112-122
DOI: 10.1038/labinvest.2012.131


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