Autoimmunity in primary antibody deficiency is associated with protein tyrosine phosphatase nonreceptor type 22 (PTPN22)
Chew, Gary Y J; Sinha, Umang; Gatenby, Paul A; DeMalmanche, Theo; Adelstein, Stephen; Garsia, Roger; Hissaria, Pravin; French, Martyn A; Wilson, Anastasia; Whittle, Belinda; Kikpatrick, Philippa; Riminton, D Sean; Fulcher, David A; Cook, Matthew C
Background The 1858T allele of protein tyrosine phosphatase nonreceptor type 22 (PTPN22; R620W) exhibits one of the strongest and most consistent associations with sporadic autoimmune disease. Although autoimmunity is common in patients with primary antibody deficiency (PAD), it remains unknown whether its pathogenesis is similar when it arises in this context compared with in immunocompetent patients. Objective We set out to determine whether the 1858T allele of PTPN22 was associated with...[Show more]
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|Source:||Journal of Allergy and Clinical Immunology|
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