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Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells

Altin, John A; Daley, Stephen R; Howitt, Jason; Rickards, Helen J; Batkin, Alison K; Horikawa, Keisuke; Prasad, Simon J; Nelms, Keats A; Kumar, Sharad; Wu, Lawren C; Tan, Seong-Seng; Cook, Matthew C; Goodnow, Christopher C


The NDFIP1 (neural precursor cell expressed, developmentally down-regulated protein 4 family-interacting protein 1) adapter for the ubiquitin ligase ITCH is genetically linked to human allergic and autoimmune disease, but the cellular mechanism by which these proteins enable foreign and self-antigens to be tolerated is unresolved. Here, we use two unique mouse strains—an Ndfip1-YFP reporter and an Ndfip1-deficient strain—to show that Ndfip1 is progressively induced during T-cell differentiation...[Show more]

CollectionsANU Research Publications
Date published: 2013-12-17
Type: Journal article
Source: PNAS 11.6 (2013):2067–2074
DOI: 10.1073/pnas.1322739111


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