Skip navigation
Skip navigation

Breakdown in repression of IFN-y mRNA leads to accumulation of self-reactive effector CD8+ T cells

Chang, Pheh-Ping; Lee, Sau K; Hu, Xin; Davey, Gayle; Duan, Guowen; Cho, Jae-Ho; Karupiah, Guna; Sprent, Jonathan; Heath, William R; Bertram, Edward M; Vinuesa, Carola

Description

Tight regulation of virus-induced cytotoxic effector CD8+ T cells is essential to prevent immunopathology. Naturally occurring effector CD8+ T cells, with a KLRG1hi CD62Llo phenotype typical of short-lived effector CD8+ T cells (SLECs), can be found in increased numbers in autoimmune-prone mice, most notably in mice homozygous for the san allele of Roquin. These SLEC-like cells were able to trigger autoimmune diabetes in a susceptible background. When Roquin is mutated (Roquinsan), effector...[Show more]

CollectionsANU Research Publications
Date published: 2012-06-08
Type: Journal article
URI: http://hdl.handle.net/1885/11401
Source: The Journal of Immunology 189.2 (2012):701-710
DOI: 10.4049/jimmunol.1102432

Download

There are no files associated with this item.


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  23 August 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator