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Breakdown in repression of IFN-y mRNA leads to accumulation of self-reactive effector CD8+ T cells

Chang, Pheh-Ping; Lee, Sau K; Hu, Xin; Davey, Gayle; Duan, Guowen; Cho, Jae-Ho; Karupiah, Guna; Sprent, Jonathan; Heath, William R; Bertram, Edward M; Vinuesa, Carola


Tight regulation of virus-induced cytotoxic effector CD8+ T cells is essential to prevent immunopathology. Naturally occurring effector CD8+ T cells, with a KLRG1hi CD62Llo phenotype typical of short-lived effector CD8+ T cells (SLECs), can be found in increased numbers in autoimmune-prone mice, most notably in mice homozygous for the san allele of Roquin. These SLEC-like cells were able to trigger autoimmune diabetes in a susceptible background. When Roquin is mutated (Roquinsan), effector...[Show more]

CollectionsANU Research Publications
Date published: 2012-06-08
Type: Journal article
Source: The Journal of Immunology 189.2 (2012):701-710
DOI: 10.4049/jimmunol.1102432


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