HIV and T follicular helper cells: a dangerous relationship
HIV infection leads to progressive destruction of infected CD4 T cells, hypergammaglobulinemia, and loss of memory B cells. Germinal centers, which are key to memory B cell formation and protective antibody responses, are major HIV reservoirs in which the virus replicates within T follicular helper (TFH) cells. In this issue of the JCI, the Koup and Streeck groups report that chronic SIV/HIV infection promotes TFH cell accumulation, which may drive B cell dysregulation. Their discoveries...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Clinical Investigation 122.9 (2012): 3059-3062|
|Vinuesa 2012 HIV and T follicular helper cells.pdf||2.18 MB||Adobe PDF|
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