Vinuesa, Carola G
HIV infection leads to progressive destruction of infected CD4 T cells,
hypergammaglobulinemia, and loss of memory B cells. Germinal centers, which are key to memory B cell formation and protective antibody responses, are major HIV reservoirs in which the virus replicates within T follicular helper (TFH) cells. In this issue of the JCI, the Koup and Streeck groups
report that chronic SIV/HIV infection promotes TFH cell accumulation, which may drive B cell dysregulation. Their discoveries...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.