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HIV and T follicular helper cells: a dangerous relationship

Vinuesa, Carola G


HIV infection leads to progressive destruction of infected CD4 T cells, hypergammaglobulinemia, and loss of memory B cells. Germinal centers, which are key to memory B cell formation and protective antibody responses, are major HIV reservoirs in which the virus replicates within T follicular helper (TFH) cells. In this issue of the JCI, the Koup and Streeck groups report that chronic SIV/HIV infection promotes TFH cell accumulation, which may drive B cell dysregulation. Their discoveries...[Show more]

CollectionsANU Research Publications
Date published: 2012-09
Type: Journal article
Source: Journal of Clinical Investigation 122.9 (2012): 3059-3062
DOI: 10.1172/JCI65175


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