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T-follicular helper cell differentiation and the co-option of this pathway by non-helper cells

Linterman, Michelle; Liston, Adrian; Vinuesa, Carola

Description

Human and mouse studies performed over the last decade have established that follicular helper T (Tfh) cells are a CD4+ helper subset specialized in the provision of help to B cells. Tfh differentiation is driven by expression of the transcriptional repressor B-cell lymphoma-6 (Bcl-6), which turns on a program that guides T cells close to B-cell areas where Tfh cells first provide help to B cells. Sustained Bcl-6 expression promotes the entry of Tfh cells into follicles and modulates their...[Show more]

CollectionsANU Research Publications
Date published: 2012-05
Type: Journal article
URI: http://hdl.handle.net/1885/11399
Source: Immunological Reviews 247.1 (2012):143–159
DOI: 10.1111/j.1600-065X.2012.01121.x.

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