Interferon-y excess leads to pathogenic accumulation of follicular helper T cells and germinal centers
Overactivity of the germinal center (GC) pathway resulting from accumulation of follicular helper T (Tfh) cells causes autoimmunity, underscoring the need to understand the factors that control Tfh cell homeostasis. Here we have identifed posttranscriptional repression of interferon-y (Ifng) mRNA as a mechanism to limit Tfh cell formation. By using the sanroque lupus model, we have shown that decreased Ifng mRNA decay caused excessive IFN-g signaling in T cells and led to accumulation of Tfh...[Show more]
|Collections||ANU Research Publications|
|Source:||Immunity 37.5 (2012): 880–892|
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