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Interferon-y excess leads to pathogenic accumulation of follicular helper T cells and germinal centers

Lee, Sau K; Silva, Diego G; Martin, Jaime L; Pratama, Alvin; Hu, Xin; Chang, Pheh Ping; Walters, Giles; Vinuesa, Carola

Description

Overactivity of the germinal center (GC) pathway resulting from accumulation of follicular helper T (Tfh) cells causes autoimmunity, underscoring the need to understand the factors that control Tfh cell homeostasis. Here we have identifed posttranscriptional repression of interferon-y (Ifng) mRNA as a mechanism to limit Tfh cell formation. By using the sanroque lupus model, we have shown that decreased Ifng mRNA decay caused excessive IFN-g signaling in T cells and led to accumulation of Tfh...[Show more]

CollectionsANU Research Publications
Date published: 2012-11-16
Type: Journal article
URI: http://hdl.handle.net/1885/11398
Source: Immunity 37.5 (2012): 880–892
DOI: 10.1016/j.immuni.2012.10.010

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