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Heterozygosity for Roquinsan leads to angioimmunoblastic T-cell lymphoma-like tumors in mice

Ellyard, Julia I; Chia, Tiongsun; Rodriguez-Pinilla, Socorro-Maria; Martin, Jaime L; Hu, Xin; Navarro-Gonzalez, Manuel; Garcia, Juan F; Delfau-Larue, Marie-Helene; Montes-Moreno, Santiago; Gaulard, Philippe; Cook, Matthew C; Walters, Giles; Piris, Miguel A; Vinuesa, Carola

Description

Angioimmunoblastic T-cell lymphoma (AITL) is the second most common peripheral T-cell lymphoma with unusual clinical and pathologic features and a poor prognosis despite intensive chemotherapy. Recent studies have suggested AITL derives from follicular helper T (TFH) cells, but the causative molecular pathways remain largely unknown. Here we show that approximately 50% of mice heterozygous for the “san” allele of Roquin develop tumors accompanied by hypergammaglobulinemia by 6...[Show more]

CollectionsANU Research Publications
Date published: 2012-07-26
Type: Journal article
URI: http://hdl.handle.net/1885/11396
Source: Blood 120.4 (2012):812-821
DOI: 10.1182/blood-2011-07-365130

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