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Innate B cell helpers reveal novel types of antibody responses

Vinuesa, Carola; Chang, Pheh-Ping

Description

Antibody responses are classified according to whether B cells receive help from T cells—that is, whether they are thymus-dependent (TD) responses or thymus-independent (TI) responses. The latter can be elicited by microbial ligands (TI type 1) or by extensive crosslinking of the B cell antigen receptor (BCR; TI type 2). The hallmark of a TD response is the induction of germinal centers in which follicular helper T cells (TFH cells) select B cells with somatically mutated high-affinity BCRs to...[Show more]

CollectionsANU Research Publications
Date published: 2013-01-18
Type: Journal article
URI: http://hdl.handle.net/1885/11395
Source: Nature Immunology 14.2 (2013): 119-126
DOI: 10.1038/ni.2511

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