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ROQUIN-2 shares overlapping functions with its paralog ROQUIN-1 in the repression of mRNAs controlling Tfh cell accumulation and systemic inflammation

Pratama, Alvin; Ramiscal, Roybel R; Silva, Diego G; Das, Souvik K; Athanasopoulos, Vicki; Fitch, Jessica; Botelho, Natalia K; Chang, Pheh-Ping; Hu, Xin; Hogan, Jennifer J; Mana, Paula; Bernal, David; Korner, Heinrich; Yu, Di; Goodnow, Christopher C; Cook, Matthew C; Vinuesa, Carola


Accumulation of T follicular helper (Tfh) cells and proinflammatory cytokines drive autoantibody-mediated diseases. The RNA-binding protein Roquin-1 (Rc3h1) represses the inducible costimulator ICOS and interferon- (IFN-) in T cells to prevent Tfh cell accumulation. Unlike Rc3h1san mice with a mutation in the ROQ domain of Roquin-1, mice lacking the protein, paradoxically do not display increased Tfh cells. Here we have analyzed mice with mutations that eliminate the RING domain from Roquin-1...[Show more]

CollectionsANU Research Publications
Date published: 2013-04-11
Type: Journal article
Source: Immunity 38.4 (2013):669-680
DOI: 10.1016/j.immuni.2013.01.011


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