Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-Regulated Pathway
Lee, James C; Espeli, Marion; Anderson, Carl A; Linterman, Michelle; Pocock, Joanna M; Williams, Naomi J; Roberts, Rebecca; Viatte, Sebastien; Fu, Bo; Peshu, Norbert; Hien, Tran Tinh; Phu, Nguyen Hoan; Wesley, Emma; Edwards, Cathryn; Ahmad, Tariq; Mansfield, John C; Gearry, Richard; Dunstan, Sarah; Williams, Thomas N; Barton, Anne; Vinuesa, Carola; UK IBD Genetics Consortium; Parkes, Miles; Lyons, Paul A; Smith, Kenneth G C
The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically determines the impact a disease has on a patient’s life but is very poorly understood. Here, we exploit existing genome-wide association study data to gain insight into the role of genetics in prognosis. We identify a noncoding polymorphism in FOXO3A (rs12212067: T > G) at which the minor (G) allele, despite not being associated with disease...[Show more]
|Collections||ANU Research Publications|
|Source:||Cell 155 (2013): 57-69|
|Lee et al Human SNP links 2013.pdf||1.8 MB||Adobe PDF|
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