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Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-Regulated Pathway

Lee, James C; Espeli, Marion; Anderson, Carl A; Linterman, Michelle A; Pocock, Joanna M; Williams, Naomi J; Roberts, Rebecca; Viatte, Sebastien; Fu, Bo; Peshu, Norbert; Hien, Tran Tinh; Phu, Nguyen Hoan; Wesley, Emma; Edwards, Cathryn; Ahmad, Tariq; Mansfield, John C; Gearry, Richard; Dunstan, Sarah; Williams, Thomas N; Barton, Anne; Vinuesa, Carola G; UK IBD Genetics Consortium; Parkes, Miles; Lyons, Paul A; Smith, Kenneth G C


The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically determines the impact a disease has on a patient’s life but is very poorly understood. Here, we exploit existing genome-wide association study data to gain insight into the role of genetics in prognosis. We identify a noncoding polymorphism in FOXO3A (rs12212067: T > G) at which the minor (G) allele, despite not being associated with disease...[Show more]

CollectionsANU Research Publications
Date published: 2013-09-26
Type: Journal article
Source: Cell 155 (2013): 57-69
DOI: 10.1037/a0032650


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