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Insights into an evolutionary strategy leading to antibiotic resistance

Hou, Chun-Feng D; Liu, Jian-Wei; Collyer, Charles; Mitić, Nataša; Pedroso, Marcelo Monteiro; Schenk, Gerhard; Ollis, David L


Metallo-β-lactamases (MBLs) with activity towards a broad-spectrum of β-lactam antibiotics have become a major threat to public health, not least due to their ability to rapidly adapt their substrate preference. In this study, the capability of the MBL AIM-1 to evade antibiotic pressure by introducing specific mutations was probed by two alternative methods, i.e. site-saturation mutagenesis (SSM) of active site residues and in vitro evolution. Both approaches demonstrated that a single mutation...[Show more]

CollectionsANU Research Publications
Date published: 2017-01-11
Type: Journal article
Source: Scientific reports
DOI: 10.1038/srep40357
Access Rights: Open Access


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