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Simian immunodeficiency virus confounds T follicular helper T cells and the germinal centre

Lea-Henry, Tom N; Jiang, Simon H

Description

Yamamoto et al. have studied T follicular helper (TFH) and germinal centre (GC) responses after infection of rhesus macaques (RM) infected with simian immunodeficiency virus (SIV). In this study the authors examined the behaviour of TFH, reproducing infection-associated TFH accumulation and their association with the quality of antibody responses against cross-clade viral epitopes. The authors correlate TFHIL4 and CD154 expression with superior antibody responses. Accumulation of TFH was...[Show more]

CollectionsANU Research Publications
Date published: 2016-12
Type: Journal article
URI: http://hdl.handle.net/1885/113756
Source: Annals of translational medicine
DOI: 10.21037/atm.2016.11.76

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