Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation
To identify rate-limiting steps in T cell-independent type 2 (TI-2) antibody production against polysaccharide antigens, we performed a genome-wide screen by immunizing several hundred pedigrees of C57BL/6 mice segregating ENU-induced mis-sense mutations. Two independent mutations, Tilcara and Untied, were isolated that semi-dominantly diminished antibody against polysaccharide but not protein antigens. Both mutations resulted from single amino acid substitutions within the kinase domain of...[Show more]
|Collections||ANU Research Publications|
|Source:||Genes and Immunity 14.4 (2013): 223-233|
|Teh et al Heterozygous mis-sense mutations in Prkcb 2013.pdf||169.4 kB||Adobe PDF|
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