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Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation

Teh, CE; Horikawa, K; Arnold, CN; Beutler, B; Kucharska, EM; Vinuesa, CG; Bertram, EM; Goodnow, CC; Enders, A


To identify rate-limiting steps in T cell-independent type 2 (TI-2) antibody production against polysaccharide antigens, we performed a genome-wide screen by immunizing several hundred pedigrees of C57BL/6 mice segregating ENU-induced mis-sense mutations. Two independent mutations, Tilcara and Untied, were isolated that semi-dominantly diminished antibody against polysaccharide but not protein antigens. Both mutations resulted from single amino acid substitutions within the kinase domain of...[Show more]

CollectionsANU Research Publications
Date published: 2013-06
Type: Journal article
Source: Genes and Immunity 14.4 (2013): 223-233
DOI: 10.1038/gene.2013.11


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