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Control of TFH cell numbers: why and how?

Pratama, Alvin; Vinuesa, Carola


T follicular helper (TFH) cells are essential for formation of germinal centres (GCs) and selection of mutated GC B cells. It has become clear over the last decade that precise control of TFH cell numbers is important to produce optimally affinity-matured antibody responses that are devoid of self-reactivity. Indeed, limiting the number of TFH cells appears important to impose competition amongst B-cell clones and set a selection threshold that will favour survival of high affinity clones....[Show more]

CollectionsANU Research Publications
Date published: 2013-11-05
Type: Journal article
Source: Immunology and Cell Biology 92 (2014): 40-48
DOI: 10.1038/icb.2013.69


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