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The Mild Behavioral Impairment Checklist (MBI-C): A Rating Scale for Neuropsychiatric Symptoms in Pre-Dementia Populations

Ismail, Zahinoor; Agüera-Ortiz, Luis; Brodaty, Henry; Cieslak, Alicja; Cummings, Jeffrey; Fischer, Corinne E; Gauthier, Serge; Geda, Yonas E; Herrmann, Nathan; Kanji, Jamila; Lanctôt, Krista L; Miller, David S; Mortby, Moyra E; Onyike, Chiadi U; Rosenberg, Paul B; Smith, Eric E; Smith, Gwenn S; Sultzer, David L; Lyketsos, Constantine

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BACKGROUND Mild behavioral impairment (MBI) is a construct that describes the emergence at ≥50 years of age of sustained and impactful neuropsychiatric symptoms (NPS), as a precursor to cognitive decline and dementia. MBI describes NPS of any severity, which are not captured by traditional psychiatric nosology, persist for at least 6 months, and occur in advance of or in concert with mild cognitive impairment. While the detection and description of MBI has been operationalized in the...[Show more]

dc.contributor.authorIsmail, Zahinoor
dc.contributor.authorAgüera-Ortiz, Luis
dc.contributor.authorBrodaty, Henry
dc.contributor.authorCieslak, Alicja
dc.contributor.authorCummings, Jeffrey
dc.contributor.authorFischer, Corinne E
dc.contributor.authorGauthier, Serge
dc.contributor.authorGeda, Yonas E
dc.contributor.authorHerrmann, Nathan
dc.contributor.authorKanji, Jamila
dc.contributor.authorLanctôt, Krista L
dc.contributor.authorMiller, David S
dc.contributor.authorMortby, Moyra E
dc.contributor.authorOnyike, Chiadi U
dc.contributor.authorRosenberg, Paul B
dc.contributor.authorSmith, Eric E
dc.contributor.authorSmith, Gwenn S
dc.contributor.authorSultzer, David L
dc.contributor.authorLyketsos, Constantine
dc.date.accessioned2017-03-15T04:01:17Z
dc.identifier.issn1387-2877
dc.identifier.urihttp://hdl.handle.net/1885/113295
dc.description.abstractBACKGROUND Mild behavioral impairment (MBI) is a construct that describes the emergence at ≥50 years of age of sustained and impactful neuropsychiatric symptoms (NPS), as a precursor to cognitive decline and dementia. MBI describes NPS of any severity, which are not captured by traditional psychiatric nosology, persist for at least 6 months, and occur in advance of or in concert with mild cognitive impairment. While the detection and description of MBI has been operationalized in the International Society to Advance Alzheimer's Research and Treatment - Alzheimer's Association (ISTAART-AA) research diagnostic criteria, there is no instrument that accurately reflects MBI as described. OBJECTIVE To develop an instrument based on ISTAART-AA MBI criteria. METHODS Eighteen subject matter experts participated in development using a modified Delphi process. An iterative process ensured items reflected the five MBI domains of 1) decreased motivation; 2) emotional dysregulation; 3) impulse dyscontrol; 4) social inappropriateness; and 5) abnormal perception or thought content. Instrument language was developed a priori to pertain to non-demented functionally independent older adults. RESULTS We present the Mild Behavioral Impairment Checklist (MBI-C), a 34-item instrument, which can easily be completed by a patient, close informant, or clinician. CONCLUSION The MBI-C provides the first measure specifically developed to assess the MBI construct as explicitly described in the criteria. Its utility lies in MBI case detection, and monitoring the emergence of MBI symptoms and domains over time. Studies are required to determine the prognostic value of MBI for dementia development, and for predicting different dementia subtypes.
dc.description.sponsorshipZI is supported by the Hotchkiss Brain Institute via the Alzheimer Society of Calgary. EES is supported by the Katthy Taylor Chair in Vascular Dementia and CIHR. DS is supported in part by the Department ofVeterans Affairs.GSis supported by National Institute of Health: AG038893 and AG041633. JC acknowledges funding from the National Institute of General Medical Sciences (Grant: P20GM109025) and support from Keep Memory Alive. MEM is supported by the Australian National Health and Medical Research Council (NHMRC) and Australian Research Council (ARC) Dementia Research Development Fellowship #1102028. SG is supported by CIHR and the Weston Brain Institute. KGL is supported in part by NIH grant P50AG005146 for the Johns Hopkins ADRC.
dc.format10 pages
dc.publisherIOS Press
dc.rights© 2017 – IOS Press and the authors. http://www.sherpa.ac.uk/romeo/issn/1387-2877/ Author can archive post-print (ie final draft post-refereeing) (Sherpa/Romeo as of 23/8/2017)
dc.sourceJournal of Alzheimer's disease : JAD
dc.subjectbehavioral and psychological symptoms of dementia
dc.subjectdementia
dc.subjectmild behavioral impairment
dc.subjectmild cognitive impairment
dc.subjectneuropsychiatric symptoms
dc.subjectpreclinical dementia
dc.subjectprodromal dementia
dc.titleThe Mild Behavioral Impairment Checklist (MBI-C): A Rating Scale for Neuropsychiatric Symptoms in Pre-Dementia Populations
dc.typeJournal article
local.identifier.citationvolume56
dcterms.dateAccepted2016-11-25
dc.date.issued2017
local.publisher.urlhttp://www.iospress.nl/
local.type.statusAccepted Version
local.contributor.affiliationMortby, Moyra E., Centre for Research on Ageing Health and Wellbeing, CMBE Research School of Population Health, Th Australian National University
dc.relationhttp://purl.org/au-research/grants/nhmrc/1102028
local.identifier.essn1875-8908
local.bibliographicCitation.issue3
local.bibliographicCitation.startpage929
local.bibliographicCitation.lastpage938
local.identifier.doi10.3233/JAD-160979
dcterms.accessRightsOpen Access
CollectionsANU Research Publications

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