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Systemic toll-like receptor ligation and selective killing of dendritic cell subsets fail to dissect priming pathways for anti-vaccinia virus CD8+ T cells

Wong, Yik Chun; Smith, Stewart A; Tscharke, David C

Description

CD8 T cell responses can be generated by direct or cross-priming mechanisms, and several mouse models have been used to reveal which of these is the most important pathway for various viruses. Among these models is systemic treatment of mice with a CpG-containing oligodeoxynucleotide (CpG) to mature all dendritic cells (DCs), rendering them incapable of cross-presentation. A second is the use of cytochrome c (cytc) as a selective poison of the subsets of DCs able to cross-present antigen. In...[Show more]

CollectionsANU Research Publications
Date published: 2013-08-28
Type: Journal article
URI: http://hdl.handle.net/1885/11323
Source: Journal of Virology 87.22 (2013):11978-11986
DOI: 10.1128/JVI.01835-13

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