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Griseofulvin impairs intraerythrocytic growth of Plasmodium falciparum through ferrochelatase inhibition but lacks activity in an experimental human infection study

Smith, Clare M; Jerkovic, Ante; Truong, Thy Thuc; Foote, Simon J; McCarthy, James S; McMorran, Brendan J

Description

Griseofulvin, an orally active antifungal drug used to treat dermatophyte infections, has a secondary effect of inducing cytochrome P450-mediated production of N-methyl protoporphyrin IX (N-MPP). N-MPP is a potent competitive inhibitor of the heme biosynthetic-enzyme ferrochelatase, and inhibits the growth of cultured erythrocyte stage Plasmodium falciparum. Novel drugs against Plasmodium are needed to achieve malaria elimination. Thus, we investigated whether griseofulvin shows anti-plasmodial...[Show more]

CollectionsANU Research Publications
Date published: 2017-02-08
Type: Journal article
URI: http://hdl.handle.net/1885/112725
Source: Scientific Reports
DOI: 10.1038/srep41975

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