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Association of genetic risk factors with cognitive decline: the PATH through life project

Andrews, Shea J; Das, Debjani; Cherbuin, Nic; Anstey, Kaarin; Easteal, Simon


We examined the association of 28 single nucleotide polymorphisms (SNPs), previously associated with dementia or cognitive performance, with tests assessing episodic memory, working memory, vocabulary, and perceptual speed in 1689 nondemented older Australians of European ancestry. In addition to testing each variant individually, we assessed the collective association of the 12-risk SNPs for late-onset Alzheimer's disease using weighted and unweighted genetic risk scores. Significant...[Show more]

CollectionsANU Research Publications
Date published: 2016-05
Type: Journal article
Source: Neurobiology of Aging
DOI: 10.1016/j.neurobiolaging.2016.02.016


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