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The implication of amino acid mutations at flavivirus NS1-2A cleavage site on NS1’ protein production

Bettadapura, J.; Addis, S. N. K.

Description

Aims: The presence of a C-terminally extended form of NS1 (NS1’ protein) has been previously reported in encephalitic flaviviruses, due to the presence of -1 programmed ribosomal frameshift at the N-terminal of NS2A protein. This present study is aimed to further confirm that the NS1’ protein production is independent of the authentic cleavage at NS1-2A junction. Methodology and results: Six different constructs (P1-Leu, P2-Asp, P3-Phe, P3-Leu, P3-Gly and P5-8 Ala) containing various...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/112403
Source: Malaysian Journal of Microbiology
DOI: 10.21161/mjm.71815

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