The implication of amino acid mutations at flavivirus NS1-2A cleavage site on NS1’ protein production
Aims: The presence of a C-terminally extended form of NS1 (NS1’ protein) has been previously reported in encephalitic flaviviruses, due to the presence of -1 programmed ribosomal frameshift at the N-terminal of NS2A protein. This present study is aimed to further confirm that the NS1’ protein production is independent of the authentic cleavage at NS1-2A junction. Methodology and results: Six different constructs (P1-Leu, P2-Asp, P3-Phe, P3-Leu, P3-Gly and P5-8 Ala) containing various...[Show more]
|Collections||ANU Research Publications|
|Source:||Malaysian Journal of Microbiology|
|01_Addis_The_Implication_of_Amino_Acid_2015.pdf||476.38 kB||Adobe PDF|
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