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Development of a registration framework to validate MRI with histology for prostate focal therapy

Reynolds, H M; Williams, S; Zhang, A; Chakravorty, R; Rawlinson, D; Ong, C S; Esteva, M; Mitchell, C; Parameswaran, B; Finnegan, M; Liney, G; Haworth, A


PURPOSE Focal therapy has been proposed as an alternative method to whole-gland treatment for prostate cancer when aiming to reduce treatment side effects. The authors recently validated a radiobiological model which takes into account tumor location and tumor characteristics including tumor cell density, Gleason score, and hypoxia in order to plan optimal dose distributions for focal therapy. The authors propose that this model can be informed using multiparametric MRI (mpMRI) and in this...[Show more]

CollectionsANU Research Publications
Date published: 2015-12
Type: Journal article
Source: Medical physics
DOI: 10.1118/1.4935343
Access Rights: Open Access


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