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Review: T follicular helper cells in transplantation

Walters, Giles Desmond; Vinuesa, Carola

Description

The recently described T follicular helper (Tfh) cell is required for the production of high affinity antibody. After contact with follicular dendritic cells, Tfh cells move into the germinal centre and provide help to B cells both by direct B cell-T cell interaction and production of IL-21. This drives proliferation, differentiation, and affinity maturation of the B cells to produce plasma cells capable of secreting high-affinity antibody. Circulating Tfh cells are produced by movement of Tfh...[Show more]

CollectionsANU Research Publications
Date published: 2016-08
Type: Journal article
URI: http://hdl.handle.net/1885/112340
Source: Transplantation
DOI: 10.1097/TP.0000000000001217

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