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B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8-dendritic cells require the intramembrane endopeptidase SPPL2A

Bergmann, Hannes; Yabas, Mehmet; Short, Alanna; Miosge, Lisa; Barthel, Nadine; Teh, Charis E; Roots, Carla; Bull, Katherine R; Jeelall, Yogesh; Horikawa, Keisuke; Whittle, Belinda; Balakishnan, Bhavani; Sjollema, Geoff; Bertram, Edward M; Mackay, Fabienne; Rimmer, Andrew J; Cornall, Richard J; Field, Matthew A; Andrews, T Daniel; Goodnow, Christopher C; Enders, Anselm


Druggable proteins required for B lymphocyte survival and immune responses are an emerging source of new treatments for autoimmunity and lymphoid malignancy. In this study, we show that mice with an inactivating mutation in the intramembrane protease signal peptide peptidase-like 2A (SPPL2A) unexpectedly exhibit profound humoral immunodeficiency and lack mature B cell subsets, mirroring deficiency of the cytokine B cell-activating factor (BAFF). Accumulation of Sppl2a-deficient B cells was...[Show more]

CollectionsANU Research Publications
Date published: 2013-01-14
Type: Journal article
Source: Journal of Experimental Medicine 210.1 (2013):31-40
DOI: 10.1084%2Fjem.20121076


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