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Follicular Helper T Cells

Vinuesa, Carola G; Linterman, Michelle A; Yu, Di; MacLennan, Ian C M

Description

Although T cell help for B cells was described several decades ago, it was the identification of CXCR5 expression by B follicular helper T (Tfh) cells and the subsequent discovery of their dependence on BCL6 that led to the recognition of Tfh cells as an independent helper subset and accelerated the pace of discovery. More than 20 transcription factors, together with RNA-binding proteins and microRNAs, control the expression of chemotactic receptors and molecules important for the function and...[Show more]

CollectionsANU Research Publications
Date published: 2016-05-20
Type: Journal article
URI: http://hdl.handle.net/1885/111768
Source: Annual review of immunology
DOI: 10.1146/annurev-immunol-041015-055605

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