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Sublinear integration underlies binocular processing in primary visual cortex

Longordo, Fabio; To, Minh-Son; Ikeda, Kaori; Stuart,Greg


Although we know much about the capacity of neurons to integrate synaptic inputs in vitro, less is known about synaptic integration in vivo. Here we address this issue by investigating the integration of inputs from the two eyes in mouse primary visual cortex. We find that binocular inputs to layer 2/3 pyramidal neurons are integrated sublinearly in an amplitude-dependent manner. Sublinear integration was greatest when binocular responses were largest, as occurs at the preferred orientation and...[Show more]

CollectionsANU Research Publications
Date published: 2013-05-05
Type: Journal article
Source: Nature Neuroscience 16.6 (2013):714-725
DOI: 10.1038/nn.3394


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