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A model of progressive photo-oxidative degeneration and inflammation in the pigmented C57BL/6J mouse retina

Natoli, Riccardo; Jiao, Haihan; Barnett, Nigel L; Fernando, Nilisha; Valter, Krisztina; Provis, Jan M; Rutar, Matt


Light-induced degeneration in rodent retinas is an established model for of retinal degeneration, including the roles of oxidative stress and neuroinflammatory activity. In these models, photoreceptor death is elicited via photo-oxidative stress, and is exacerbated by recruitment of subretinal macrophages and activation of immune pathways including complement propagation. Existing light damage models have relied heavily on albino rodents, and mostly using acute light stimuli. These albino...[Show more]

CollectionsANU Research Publications
Date published: 2016-06
Type: Journal article
Source: Experimental eye research
DOI: 10.1016/j.exer.2016.04.015


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