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Structural and dynamic perspectives on the promiscuous transport activity of P-glycoprotein

Subramanian, Nandhitha; Condic-Jurkic, Karmen; O'Mara, Megan

Description

The multidrug transporter P-glycoprotein (P-gp) is expressed in the blood-brain barrier endothelium where it effluxes a range of drug substrates, preventing their accumulation within the brain. P-gp has been studied extensively for 40 years because of its crucial role in the absorption, distribution, metabolism and elimination of a range of pharmaceutical compounds. Despite this, many aspects of the structure-function mechanism of P-gp are unresolved. Here we review the emerging role of...[Show more]

CollectionsANU Research Publications
Date published: 2016-09
Type: Journal article
URI: http://hdl.handle.net/1885/111425
Source: Neurochemistry international
DOI: 10.1016/j.neuint.2016.05.005

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