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The Role of Pyruvate in Protecting 661W Photoreceptor-Like Cells Against Light-Induced Cell Death

Natoli, Riccardo; Rutar, Matt; Lu, Yen-Zhen; Chu-Tan, Joshua A; Chen, Yuwei; Saxena, Kartik; Madigan, Michele; Valter, Krisztina; Provis, Jan M


PURPOSE Light is a requirement for the function of photoreceptors in visual processing. However, prolonged light exposure can be toxic to photoreceptors, leading to increased reactive oxygen species (ROS), lipid peroxidation, and photoreceptor cell death. We used the 661W mouse cone photoreceptor-like cell line to study the effects of pyruvate in protecting these cells from light-induced toxicity. METHODS 661W cells were exposed to 15,000 lux continuous bright light for 5 hours and incubated in...[Show more]

CollectionsANU Research Publications
Date published: 2016-11
Type: Journal article
Source: Current eye research
DOI: 10.3109/02713683.2016.1139725


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