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Efficient experimental design and analysis strategies for the detection of differential expression using RNA-Sequencing

Robles, José A; Qureshi, Sumaira E; Stephen, Stuart J; Wilson, Susan R; Burden, Conrad J; Taylor, Jennifer M


Background: RNA sequencing (RNA-Seq) has emerged as a powerful approach for the detection of differential gene expression with both high-throughput and high resolution capabilities possible depending upon the experimental design chosen. Multiplex experimental designs are now readily available, these can be utilised to increase the numbers of samples or replicates profiled at the cost of decreased sequencing depth generated per sample. These strategies impact on the power of the approach to...[Show more]

CollectionsANU Research Publications
Date published: 2012-09-17
Type: Journal article
Source: BMC Genomics 13:484 (2012)
DOI: 10.1186/1471-2164-13-484


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