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Advancing the Escherichia coli Glucuronylsynthase: Kinetics and Synthetic Applications

Ma, Paul


The Escherichia coli glucuronylsynthase is an engineered glycosynthase enzyme derived from wild-type E. coli β-glucuronidase where a single-point mutation has changed the function of the enzyme from a hydrolase to a synthase. The glucuronylsynthase catalyses the formation of a glycosidic bond between a glucopyranuronic acid moiety and an alcohol acceptor to yield a glucuronide compound. Glucuronides are an important class of compounds in pharmacology and...[Show more]

CollectionsOpen Access Theses
Date published: 2016
Type: Thesis (PhD)


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