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Sequence-Structure-Function Classification of a Catalytically Diverse Oxidoreductase Superfamily in Mycobacteria

Ahmed, F Hafna; Carr, Paul D; Lee, Brendon M; Afriat-Jurnou, Livnat; Mohamed, A Elaaf; Hong, Nan-Sook; Flanagan, Jack; Taylor, Matthew C; Greening, Chris; Jackson, Colin J


The deazaflavin cofactor F420 enhances the persistence of mycobacteria during hypoxia, oxidative stress, and antibiotic treatment. However, the identities and functions of the mycobacterial enzymes that utilize F420 under these conditions have yet to be resolved. In this work, we used sequence similarity networks to analyze the distribution of the largest F420-dependent protein family in mycobacteria. We show that these enzymes are part of a larger split β-barrel enzyme superfamily...[Show more]

CollectionsANU Research Publications
Date published: 2015-11-06
Type: Journal article
Source: Journal of molecular biology
DOI: 10.1016/j.jmb.2015.09.021


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