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Na⁺ regulation in the intraerythrocytic malaria parasite

Spillman, Natalie Jane

Description

The maintenance of a low intracellular [Na⁺] ([Na⁺]i) is a crucial aspect of cellular physiology. In mammalian cells this is achieved through the extrusion of Na⁺ via the well-characterised Na⁺/K⁺-ATPase. Approximately 12 hr after invasion of the human erythrocyte by the malaria parasite there is a profound increase in the permeability of the erythrocyte membrane to a wide range of solutes, including Na⁺. Na⁺ enters the infected erythrocyte via parasite-induced 'New Permeability Pathways'...[Show more]

CollectionsOpen Access Theses
Date published: 2011-12
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/109806

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