Arsenicin A : synthesis, derivatisation and biological activity
The improved synthesis and resolution of the first naturally occurring polyarsenical, Arsenicin A [As₄0₃(CH₂)₃] has been achieved. The putative structure of Arsenicin A resembled that of arsenic(III) oxide (As40 6) , but where three of the oxygen atoms in the inorganic oxide had been replaced by methylene groups in a chiral C2 arrangement. The five-step synthesis involves reduction of methylenebis(phenylarsinic acid) to the bis( secondary arsine) (RAs * ,RAs *)-( ± )/(RAs * ,S As *)-CH2[...[Show more]
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