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Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition

Wong, M-L; Inserra, A; Lewis, M D; Mastronardi, C A; Leong, L; Choo, J; Kentish, S; Xie, P; Morrison, M; Wesselingh, S L; Rogers, G B; Licinio, J

Description

The inflammasome is hypothesized to be a key mediator of the response to physiological and psychological stressors, and its dysregulation may be implicated in major depressive disorder. Inflammasome activation causes the maturation of caspase-1 and activation of interleukin (IL)-1β and IL-18, two proinflammatory cytokines involved in neuroimmunomodulation, neuroinflammation and neurodegeneration. In this study, C57BL/6 mice with genetic deficiency or pharmacological inhibition of caspase-1 were...[Show more]

CollectionsANU Research Publications
Date published: 2016-06
Type: Journal article
URI: http://hdl.handle.net/1885/109174
Source: Molecular psychiatry
DOI: 10.1038/mp.2016.46

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