Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition
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Wong, M-L; Inserra, A; Lewis, M D; Mastronardi, C A; Leong, L; Choo, J; Kentish, S; Xie, P; Morrison, M; Wesselingh, S L; Rogers, G B; Licinio, J
Description
The inflammasome is hypothesized to be a key mediator of the response to physiological and psychological stressors, and its dysregulation may be implicated in major depressive disorder. Inflammasome activation causes the maturation of caspase-1 and activation of interleukin (IL)-1β and IL-18, two proinflammatory cytokines involved in neuroimmunomodulation, neuroinflammation and neurodegeneration. In this study, C57BL/6 mice with genetic deficiency or pharmacological inhibition of caspase-1 were...[Show more]
Collections | ANU Research Publications |
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Date published: | 2016-06 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/109174 |
Source: | Molecular psychiatry |
DOI: | 10.1038/mp.2016.46 |
Access Rights: | Open Access |
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01_Wong_Inflammasome_Signaling_2016.pdf | 692.25 kB | Adobe PDF |
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