System-L amino acid transporters play a key role in pancreatic β-cell signalling and function
The branched-chain amino acids (BCAA) leucine, isoleucine and valine, are essential amino acids that play a critical role in cellular signalling and metabolism. They acutely stimulate insulin secretion and activate the regulatory serine/threonine kinase mammalian target of rapamycin complex 1 (mTORC1), a kinase that promotes increased β-cell mass and function. The effects of BCAA on cellular function are dependent on their active transport into the mammalian cells via amino acid transporters...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of molecular endocrinology|
|01_Cheng_System-L_amino_2016.pdf||1.48 MB||Adobe PDF|
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