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System-L amino acid transporters play a key role in pancreatic β-cell signalling and function

Cheng, Qi; Beltran, Violeta D; Chan, Stanley M H; Brown, Jeremy R; Bevington, Alan; Herbert, Terence P


The branched-chain amino acids (BCAA) leucine, isoleucine and valine, are essential amino acids that play a critical role in cellular signalling and metabolism. They acutely stimulate insulin secretion and activate the regulatory serine/threonine kinase mammalian target of rapamycin complex 1 (mTORC1), a kinase that promotes increased β-cell mass and function. The effects of BCAA on cellular function are dependent on their active transport into the mammalian cells via amino acid transporters...[Show more]

CollectionsANU Research Publications
Date published: 2016-04
Type: Journal article
Source: Journal of molecular endocrinology
DOI: 10.1530/JME-15-0212


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