Skip navigation
Skip navigation

Heterogeneous and Dynamic Prevalence of Asymptomatic Influenza Virus Infections

Furuya-Kanamori, Luis; Cox, Mitchell; Milinovich, Gabriel J; Magalhaes, Ricardo J Soares; Mackay, Ian M; Yakob, Laith

Description

Influenza infection manifests in a wide spectrum of severity, including symptomless pathogen carriers. We conducted a systematic review and meta-analysis of 55 studies to elucidate the proportional representation of these asymptomatic infected persons. We observed extensive heterogeneity among these studies. The prevalence of asymptomatic carriage (total absence of symptoms) ranged from 5.2% to 35.5% and subclinical cases (illness that did not meet the criteria for acute respiratory or...[Show more]

dc.contributor.authorFuruya-Kanamori, Luis
dc.contributor.authorCox, Mitchell
dc.contributor.authorMilinovich, Gabriel J
dc.contributor.authorMagalhaes, Ricardo J Soares
dc.contributor.authorMackay, Ian M
dc.contributor.authorYakob, Laith
dc.date.accessioned2016-09-22T06:04:56Z
dc.date.available2016-09-22T06:04:56Z
dc.identifier.issn1080-6040
dc.identifier.urihttp://hdl.handle.net/1885/108946
dc.description.abstractInfluenza infection manifests in a wide spectrum of severity, including symptomless pathogen carriers. We conducted a systematic review and meta-analysis of 55 studies to elucidate the proportional representation of these asymptomatic infected persons. We observed extensive heterogeneity among these studies. The prevalence of asymptomatic carriage (total absence of symptoms) ranged from 5.2% to 35.5% and subclinical cases (illness that did not meet the criteria for acute respiratory or influenza-like illness) from 25.4% to 61.8%. Statistical analysis showed that the heterogeneity could not be explained by the type of influenza, the laboratory tests used to detect the virus, the year of the study, or the location of the study. Projections of infection spread and strategies for disease control require that we identify the proportional representation of these insidious spreaders early on in the emergence of new influenza subtypes or strains and track how this rate evolves over time and space.
dc.description.sponsorshipThis work was supported by an Endeavour Postgraduate Scholarship (no. 3781_2014), an Australia National University Higher Degree Scholarship, and a Fondo para la Innovación, Ciencia, y Tecnología Scholarship (no. 095-FINCyT-BDE-2014) to L.F.K. The salary for G.J.M. was provided through the National Health and Medical Research Council, Australia (grant no. 1002608).
dc.publisherCenters for Disease Control and Prevention
dc.rightshttp://wwwnc.cdc.gov/eid/page/copyright-and-disclaimers..."Materials published in Emerging Infectious Diseases, including text, figures, tables, and photographs are in the public domain and can be reprinted or used without permission" from the publisher site (as at 22/09/16).
dc.sourceEmerging infectious diseases
dc.source.urihttp://wwwnc.cdc.gov/eid/article/22/6/15-1080_article
dc.subjectasymptomatic
dc.subjectflu
dc.subjectinfluenza
dc.subjectmeta-analysis
dc.subjectpandemic
dc.subjectprevalence
dc.subjectsubclinical
dc.subjectsymptomless proportion
dc.titleHeterogeneous and Dynamic Prevalence of Asymptomatic Influenza Virus Infections
dc.typeJournal article
local.identifier.citationvolume22
dc.date.issued2016-06
local.identifier.ariespublicationu5684624xPUB95
local.identifier.ariespublicationu5684624xPUB95
local.type.statusPublished Version
local.contributor.affiliationFuruya-Kanamori, L., Research School of Population Health, The Australian National University
dc.relationhttp://purl.org/au-research/grants/nhmrc/1002608
local.identifier.essn1080-6059
local.bibliographicCitation.issue6
local.bibliographicCitation.startpage1052-6
local.bibliographicCitation.lastpage1056
local.identifier.doi10.3201/eid2206.151080
dcterms.accessRightsOpen Access
CollectionsANU Research Publications

Download

File Description SizeFormat Image
01_Furuya-Kanamori_Heterogeneous_and_Dynamic_2016.pdf651.17 kBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator