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Model building to facilitate understanding of Holliday junction and heteroduplex formation, and Holliday junction resolution

Selvarajah, Geeta; Selvarajah, Susila

Description

Students frequently expressed difficulty in understanding the molecular mechanisms involved in chromosomal recombination. Therefore, we explored alternative methods for presenting the two concepts of the double-strand break model: Holliday junction and heteroduplex formation, and Holliday junction resolution. In addition to a lecture and computer-animated video, we included a model building activity using pipe cleaners. Biotechnology undergraduates (n = 108) used the model to simulate Holliday...[Show more]

CollectionsANU Research Publications
Date published: 2016-07
Type: Journal article
URI: http://hdl.handle.net/1885/108866
Source: Biochemistry and molecular biology education
DOI: 10.1002/bmb.20964

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