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Identification of RNA-binding proteins in macrophages by interactome capture

Liepelt, Anke; Naarmann-de Vries, Isabel S.; Simons, Nadine; Eichelbaum, Katrin; Föhr, Sophia; Archer, Stuart K.; Castello, Alfredo; Usadel, Bjorn; Krijgsveld, Jeroen; Preiss, Thomas; Marx, Gernot; Hentze, Matthias W.; Ostareck, Dirk H.; Ostareck-Lederer, Antje


Pathogen components, such as lipopolysaccharides of Gram-negative bacteria that activate Toll-like receptor 4, induce mitogen activated protein kinases and NFκB through different downstream pathways to stimulate pro- and anti-inflammatory cytokine expression. Importantly, post-transcriptional control of the expression of Toll-like receptor 4 downstream signaling molecules contributes to the tight regulation of inflammatory cytokine synthesis in macrophages. Emerging evidence highlights the role...[Show more]

CollectionsANU Research Publications
Date published: 2016-06-08
Type: Journal article
Source: Molecular & cellular proteomics
DOI: 10.1074/mcp.M115.056564
Access Rights: Open Access


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