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Striatal morphology correlates with frontostriatal electrophysiological motor processing in Huntington's disease: an IMAGE-HD study

Turner, Lauren M.; Jakabek, David; Wilkes, Fiona A.; Croft, Rodney J.; Churchyard, Andrew; Walterfang, Mark; Velakoulis, Dennis; Looi, Jeffrey C. L.; Apthorp, Apthorp; Georgiou-Karistianis, Nellie


BACKGROUND: Huntington’s disease (HD) causes progressive atrophy to the striatum, a critical node in frontostriatal circuitry. Maintenance of motor function is dependent on functional connectivity of these premotor, motor, and dorsolateral frontostriatal circuits, and structural integrity of the striatum itself. We aimed to investigate whether size and shape of the striatum as a measure of frontostriatal circuit structural integrity was correlated with functional...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
Source: Brain and Behavior
DOI: 10.1002/brb3.511


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