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Physiology, Biochemistry, and Applications of F420- and Fo-Dependent Redox Reactions

Greening, Chris; Ahmed, F Hafna; Mohamed, A Elaaf; Lee, Brendon M; Pandey, Gunjan; Warden, Andrew C; Scott, Colin; Oakeshott, John Graham; Taylor, Matthew C; Jackson, Colin J


5-Deazaflavin cofactors enhance the metabolic flexibility of microorganisms by catalyzing a wide range of challenging enzymatic redox reactions. While structurally similar to riboflavin, 5-deazaflavins have distinctive and biologically useful electrochemical and photochemical properties as a result of the substitution of N-5 of the isoalloxazine ring for a carbon. 8-Hydroxy-5-deazaflavin (Fo) appears to be used for a single function: as a light-harvesting chromophore for DNA photolyases across...[Show more]

CollectionsANU Research Publications
Date published: 2016-04-27
Type: Journal article
Source: Microbiology and Molecular Biology Reviews
DOI: 10.1128/MMBR.00070-15
Access Rights: Open Access


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